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It is not known. The sequel to Avatar (which will not be called Avatar 2 because Jake became a Na'vi forever), will take place several years after Avatar, so there is a slight chance Jake and Neytiri will have children, however, the Na'vi mating process DOES NOT guarantee offspring.

EDIT: Given how extremely little we know about the mating process (other than that it involves connecting queues) it could guarantee children.

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